- A rare disorder is associated with zinc deficiency.
- The classic triad of Peri-acral and periorificial dermatitis+ Diarrhoea &Alopeci
- Primary: inherited zinc transporter defect, resulting in reduced intestinal absorption of zinc (Danbolt-Closs syndrome, and Brandt syndrome)
- Secondary: Acquired due to reduced intake, increased demand, malabsorption, or may rarely be associated with certain metabolic disorders.