Medical Criteria – S
STOPP/START CRITERIA:
- Another screening tool for potentially inappropriate prescribing in the elderly
- STOPP: Screening Tool of Older Person’s Prescriptions
- Systems-based list of medications contraindicated in adults ≥65 in the context of their diagnoses
- START: Screening Tool to Alert doctors to Right Treatment
- Systems-based list of medications indicated in adults ≥65 in the context of their diagnoses
SEPSIS AND SEPTIC SHOCK:
- qSOFA score used initially to screen patients for suspected sepsis using three criteria:
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- respiratory rate >22/min
- systolic BP <100 mmHg
- altered mentation (GCS <15)
SCHIZOPHRENIA:
- DSM-5 DIAGNOSTIC CRITERIA FOR SCHIZOPHRENIA
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- Two (or more) of the following, each present for a significant portion of time during a 1 month period (or less if successfully treated). At least one of these must be (1),
(2), or (3)
- Two (or more) of the following, each present for a significant portion of time during a 1 month period (or less if successfully treated). At least one of these must be (1),
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- Delusions
- Hallucinations
- Disorganized speech (i.e., frequent derailment or incoherence)
- Grossly disorganized or catatonic behaviour
- Negative symptoms (i.e., diminished emotional expression or avolition)
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-
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- Decreased level of function: for a significant portion of time since onset, one or more major areas affected (i.e., work, interpersonal relations, self-care) is markedly
decreased (or if childhood/adolescent onset, failure to achieve expected level)
- Decreased level of function: for a significant portion of time since onset, one or more major areas affected (i.e., work, interpersonal relations, self-care) is markedly
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- At least 6 months of continuous signs of the disturbance. Must include at least 1 month of symptoms (or less if successfully treated) that meet Criterion A (i.e., active-
phase symptoms) and may include periods of prodromal or residual symptoms, during which, disturbance may manifest by only negative symptoms or by two or more
Criterion A symptoms present in an attenuated form (i.e., odd beliefs, unusual perceptual experiences)
- At least 6 months of continuous signs of the disturbance. Must include at least 1 month of symptoms (or less if successfully treated) that meet Criterion A (i.e., active-
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- Rule out schizoaffective disorder and depressive or bipolar disorder with psychotic features because either 1) no major depressive or manic episodes have occurred
concurrently with the active-phase symptoms, or 2) if mood episodes have occurred during active-phase symptoms, they have been present for a minority of the total
duration of the active and residual periods of the illness - Rule out other causes: GMC, substances (i.e. drug of abuse, medication)
- If history of autism spectrum disorder or communication disorder of childhood onset, the additional diagnosis of schizophrenia is made only if prominent delusions or
hallucinations are also present for at least 1 month (or less if successfully treated)
- Rule out schizoaffective disorder and depressive or bipolar disorder with psychotic features because either 1) no major depressive or manic episodes have occurred
- Specifiers: type of episode (i.e., first episode, multiple episodes, continuous), with catatonia, current severity based on quantitative assessment of primary symptoms of psychosis (in acute episode, in partial remission, in full remission.
SCHIZOPHRENIFORM DISORDER:
- Diagnosis Criteria
- Criteria A, D, and E of schizophrenia are met; an episode of the disorder lasts for at least 1 month but less than 6 months.
SCHIZOAFFECTIVE DISORDER
- Dsm-5 Diagnostic Criteria for Schizoaffective Disorder
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- Concurrent psychosis (criterion A of schizophrenia) and major mood episode – uninterrupted period of illness
- Delusions or hallucinations for 2 or more wks. in the absence of a major mood episode during the lifetime duration of the illness
- Major mood episode symptoms are present for the majority of the total duration of the active and Residual periods of the illness
- The disturbance is not attributable to the effects of a substance or another medical condition
- Specifiers: Bipolar type, depressive type, with catatonia, type of episode, severity
SUBSTANCE-RELATED AND ADDICTIVE DISORDERS:
- Substance use disorders are measured on a continuum from mild to severe based on the number of criteria met within 12 months
- Mild: 2-3
- Moderate: 4-5
- Severe: 6 or more
- Each specific substance is addressed as a separate use disorder and diagnosed utilizing the same overarching criteria (i.e., a single patient may have moderate alcohol use disorder, and a mild stimulant use disorder)
- Testing for illicit drugs is most commonly done on urine or blood samples
- Serum toxicology screen is needed to assess alcohol level
- Toxicology may be helpful in differentiating withdrawal from other mental disorders
- Criteria for substance use disorders (PEC WITH MCAT)
- Use despite physical or psychological problem (i.e., alcoholic liver disease or cocaine related nasal problems)
- Failures to fulfil external roles at work/school/home
- Craving or a strong desire to use substance
- Withdrawal
- Continued use despite interpersonal problems
- Tolerance, needing to use more substance to get same eect
- Use in physically hazardous situations
- More substance used or for longer period than intended
- Unsuccessful attempts to cut down
- Activities given up due to substance
- Excessive time spent on using or finding substance
SOMATIC SYMPTOM DISORDER:
- DSM-5 Diagnostic Criteria for Somatic Symptom Disorder
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- One or more somatic symptoms that are distressing or result in signicant disruption of daily life
- Excessive thoughts, feelings, or behaviours related to the somatic symptoms or associated health concerns as manifested by at least one of the following:
- Disproportionate and persistent thoughts about the seriousness of one’s symptoms
- Persistently high level of anxiety about health or symptoms
- Excessive time and energy devoted to these symptoms or health concerns
- Although any one somatic symptom may not be continuously present, the state of being symptomatic is persistent (typically >6 months)
- Somatic symptom disorder with predominant pain (previously pain disorder) for those whose somatic symptom is primarily pain
- Patients have physical symptoms and believe these symptoms represent the manifestation of a serious illness
- Persistent belief despite negative medical investigations and may develop different symptoms over time
- Lifetime prevalence may be around 5-7% in the general adult population
- Females tend to report more somatic symptoms than males do, cultural factors may influence sex ratio
- Complications: anxiety and depression commonly comorbid (up to 80%), unnecessary medications, or surgery
- Often a misdiagnosis for an insidious illness, so rule out all organic illnesses (i.e., multiple sclerosis)
SLEEP DISORDERS:
- Criteria
- Must cause significant distress or impairment in normal functioning
- Not due to a GMC or medications/drugs (unless specified)
SEPSIS:
- Signs and Symptoms criteria
- New guidelines recommend the use of quick SOFA (qSOFA) criteria and SOFA score to replace SIRS criteria
- In patients with suspected infection, bedside application of qSOFA criteria identifies individuals with high likelihood of poor outcomes, including prolonged ICU stay and/or death
- A positive qSOFA (≥2 criteria) should prompt application of the SOFA score, and further evaluation of possible infection and organ dysfunction
- In the context of suspected infection, a SOFA score ≥2 reflects an overall mortality risk of 10%
- The absence of ≥2 criteria on either qSOFA or SOFA score should not delay or defer investigation or treatment of infection or any other aspect of care deemed necessary by the practitioners
SEROPOSITIVE RHEUMATIC DISEASE:
- Diagnostic criteria are selected for sensitivity, as opposed to specificity, thus may misdiagnose some cases
- Classification criteria are developed for specificity so well-defined cases can be studied in clinical trials
- Modern classification criteria are more sensitive and specific for diagnostic use in studies of earlier disease
SYSTEMIC LUPUS ERYTHEMATOSUS:
- Diagnostic Criteria of SLE*
Criteria | Description |
CLINICAL | |
Malar rash | Classic “butterfly rash”, sparing of nasolabial folds, no scarring |
Discoid rash | May cause scarring due to invasion of basement membrane |
Photosensitivity | Skin rash in reaction to sunlight |
Oral/nasal ulcers | Usually, painless |
Arthritis | Symmetric, involving ≥2 small or large peripheral joints, non-erosive |
Serositis | Pleuritis or pericarditis |
Neurologic disorder | Headache, seizures or psychosis, peripheral neuropathies |
LABORATORY | |
Renal disorder | Proteinuria (>0.5 g/d or 3+)
Cellular casts (RBC, Hb, granular, tubular, mixed) |
Hematologic disorder | Haemolytic anaemia, leukopenia, lymphopenia, thrombocytopenia |
Immunologic disorder | Anti-dsDNA or anti-Sm or antiphospholipid Ab (anticardiolipin Ab, SLE anticoagulant) or false positive VDRL with 6 months confirmatory negative |
ANA | Most sensitive test (98%), not specific, ruling out SLE when negative |
*Note: “4, 7, 11” rule → 4 (or more) out of 11 criteria (4 lab, 7 clinical) must be present, serially or simultaneously, for diagnosis
- American College of Rheumatology, 1997 update
DIAGNOSTIC CRITERIA OF SYSTEMIC LUPUS ERYTHEMATOSUS:
- MD SOAP BRAIN
Malar rash | Blood |
Discoid rash | Renal |
Serositis | Arthritis |
Oral ulcers | Immune |
ANA | Neurologic |
Photosensitivity |
SCLERODERMA:
- Criteria for Scleroderma*
- The American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR)
Item | Sub-item | Score |
1. Skin thickening of fingers of both hands extending proximal to the MCP (sufficient criterion) | 9 | |
2. Skin thickening of the fingers |
|
2
4 |
3. Fingertip lesions |
|
2
3 |
4. Telangiectasia | 2 | |
5. Abnormal nailfold capillaries | 2 | |
6. Pulmonary arterial HTN ± ILD (max score 2) |
|
2
2 |
7. Raynaud’s phenomenon | 3 | |
8. Scleroderma related Ab |
|
3 |
* Score of ≥9 is sufficient to classify a patient as having definite scleroderma (sensitivity 0.95, specificity 0.93) Arthritis & Rheum 2013;65(11):2737-2747
SJÖGREN’S SYNDROME:
- Criteria for Primary Sjögren’s Syndrome (no condition in exclusion criteria, score ≥6)
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- The American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR)
Criteria | Score | Comments |
Labial salivary gland biopsy with focal lymphocytic
sialadenitis with focus score ≥1 focus /4mm2 |
3 |
|
Anti-SSA or Ro positive | 3 | |
Ocular staining score ≥5 (or van Bijsterfeld score ≥4
on at least one eye |
1 |
|
Schirmer’s test ≤5 mm / 5 min on at least one eye | 1 | |
Unstimulated whole saliva flow rate ≤0.1 mL/min | 1 | |
Exclusion criteria include prior diagnosis of any of the following conditions: 1) history of head and neck radiation treatment, 2) active hepatitis C infection (with confirmation by polymerase chain reaction, 3) AIDS, 4) sarcoidosis, 5) amyloidosis, 6) graft-versus-host disease, 7) IgG4-related disease |
- Arthritis Rheumatol. 2017; 69:35-45