Medical Genetics Syllabus in Russia, Other CIS & Eastern Europe
- Subject: Medical Genetics
- Semesters: 1 semester in 2nd or 3rd year
- Tentative hours of lectures: 50 hours
- Tentative hours of practicals: 0 hours
- Exam: internal exam (Zachiot)
- Emphasis on the CIS syllabi: It’s wise to emphasize that this Curriculum/syllabus is tentative & the subject’s distribution or teaching hours or exams might vary in different universities and CIS.
Brief description of the course
- The genetic basis of pathology is the study of the pathogenesis of diseases at a molecular level or from gene expression to pathologic metabolites formations.
- Gene diseases classification: Chromosome diseases, classification, and characteristic of the spread, Risk factors of children birth with anomalies. Monogenic and polygenic forms of the disease.
- Ecological genetics. Pharmacogenetics Cytogenic, biochemical molecular-genetic methods of research.
- Treatment and prophylaxis of hereditary pathologies. Genetic consultation.
- Prenatal diagnostic. Preimplantation diagnostic. Preclinical diagnostic and prophylaxis treatment. Screening test programs.
Objectives:
- To understand the roles of genetic damage for adequate diagnostics and prophylaxis of inheritance and other diseases.
- To form a vision about general principles of molecular-genetic methods use to theoretical and practical medicine
- To form a vision about norm and pathology in the study of genetics mechanisms on cellular & organic levels.
Prerequisites:
- Molecular biology and medical genetics
Educational methods:
- Lectures
- Practical lessons, seminars
- Active methods of education: team-based learning (TBL), problem-based learning (PBL), press conferences
- Traditional methods: work in pairs, work with textbook, situational tasks solution, discussing of student individual works, testing, microscopy, and micro slides drawing.
- Independent works: project/presentation, essay, abstract preparation.
Lectures: topics & number of hours
Topics | Hours |
1. Molecular mechanism of functional disorders of biological membrane | 2 hours |
2. Molecular mechanism of intracellular organoids functions disorders | 2 hours |
3. Molecular disorders of genetic apparatus of the cell | 2 hours |
4. Variability of hereditary characters as base of pathology. Mutation as a base factor of hereditary pathology | 2 hours |
5. Genetic effect under influence of ionizing emission | 2 hours |
6. Current control – colloquy | 2 hours |
7. Molecular-genetic disorders of metabolism diseases | 2 hours |
8. Classification of inheritance disorders. Methods of diagnostic and prophylaxis of gene diseases | 2 hours |
9. Analysis of clinical cases of gene diseases | 2 hours |
10. Nonspecific effects of chromosomal pathologies. Methods of diagnostic and prophylaxis of chromosomal diseases | 2 hours |
11. Analysis of clinical cases of chromosomal diseases | 2 hours |
12. Classification of disorders with non-traditional types of inheritance | 2 hours |
13. Molecular-genetic disorders of somatic and generative cells. Mechanism of ontogenetic disorders | 2 hours |
14. Role of environment for ontogenesis | 2 hours |
15. Teratogenic factors and carcinogenesis | 2 hours |
16. Etiology and pathogenesis of reproductive system | 2 hours |
17. Pathogenetic prophylaxis of reproductive health | 2 hours |
18. Genetic of aging | 2 hours |
19. Current control – colloquy | 2 hours |
20. Common characteristic of genetic predisposed disorders | 2 hours |
21. Laboratory methods of inherited pathology diagnostic. Genetic counseling | 2 hours |
22. General methods of genetic analysis: PCR-diagnostic | 2 hours |
23. General methods of genetic analysis: twins study, genealogical method, population genetics | 2 hours |
24. Final control | 2 hours |
Total: | 48 hours |
Interim assessments (Controls)
- MCQs + situational tasks & Viva
Sample Control & Exam questions
MCQ
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Viva |
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Situational tasks |
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Scores
- The score ranges from 5 to 1:
- 5 is “excellent” → Otlichno
- 4 is “good” → Khorosho
- 3 is “satisfactory” → Udovletvoritel’no
- 2 is “unsatisfactory” → Neudovletvoritel’no
Reference textbooks
- Passarde E. Color Atlas of Genetics. Stattgart. New York: Thieme, 2007. – 486 p.
- Brown T.A. Genetics a molecular approach. – New York: Chapman and Hall, 1990. – 387 p.
- Cell / adap.: Koykov V.V., Tankibaeva N.U., Kultanov B.J. – Karaganda. 2003. – 51 p.
- Koykov V.V. Genetics: Educational manual for students of medical faculty. – Karaganda. 2003. – 74 p.
- Dorothy E. Core concepts in clinical molecular biology. – Philadelphia, New York: Lippincott-Raven publisher, 1997. – 74 p.
- Strachan T. Human molecular genetics. – Oxford, New York, 1997. – 700 p.
Also Watch:
- Traditional Lecture in Medical Genetics (Russian language):